货号（Catalog No.）

CSD00292

通用名INN

Nivolumab

纯度(Purity)

>95%

浓度( Concentration)

1mg/ml

Formulation

PBS buffer PH7.5

Source

CHO cells

内毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

产品描述(Description)

Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.

别名(Alternative names)

BMS-936558,MDX-1106,ONO-4538

靶点;物种(Specificity target name;species)

PDCD1/PD1/CD279[Homo sapiens]

活性研究（体外/体内研究）(Activity in vitro)

Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus.

种类(Species)

Homo sapiens

受体鉴定(Receptor identification)

IgG4-kappa

化学信息

分子量(MV)

143599.09 Da

CAS

946414-94-4

存储条件(Storage)

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.

Note

For research use only .